Most brakes fit on a Lefty 2.0 or SuperMax brake adapter just fine. Some four piston brakes do make contact with the Cannondale brake adapter. Cannondale modified these adapters when they came on bikes with larger two or four piston brakes such as Magura MT5 or MT7.
One way to work with that is to use the next size bigger rotor and add the appropriate post to post adapter on top of the Cannondale adapter. That will help in many cases but not all.
Below is a picture of a modified adapter for reference.